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MSM® DES Sirolimus


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The MSM Sirolimus Eluting Coronary Stent System convinces with its trusted Cobalt Chromium Platform and the largest size portfolio available.

A fully biodegradable polymer coating containing Sirolimus (Rapamycin), enables controlled drug release preventing early thrombotic events and stent restenosis.

The biocompatible PLGA Polymer provides consistent, controlled and a 100 % drug release. The Polymer degrades 100 % into carbon dioxide and water.

The decreased profile results in an increased flexibility and enables an easy side branch access.

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Safety and Efficiency of Sirolimus

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Sirolimus acts on G1 phase of cell cycle, preventing cell from entering S phase and inhibiting SMC proliferation and inflammation.

Effective Factor - Drug

Acting on G1 phase or M phase has different effects

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Polymer Coating of MSM Sirolimus
PLGA 85/15 Biocompatible Polymer

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The thickness of biodegradable polymer-coating is only 5 μm, thinner coating increases the ability and effectiveness of delivery.

Advanced Coating Technology

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During the age of DES, it is very important for stent to remain uniform and smooth after deployment.

Advanced Surface treatment & Coating Technology

During expansion
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Unique technology for the metal
surface treatment, and
advanced spraying procedure

After expansion
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Great anti-deformability
Coating uniform
No collapse

Factor that affects efficacy Polymer Coating

drug releasing pattern would affect the whole process of restenosis

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Four courses of intimal repairing can cause restenosis

  • Platelet deposition occurring in 15 days after stent implantation
  • Leukocyte recruitment occurring in 50 days
  • SMC migration/proliferation occurring in 90 days
  • Matrix deposition occurring after 120 days

Drug Release Rate

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90-days drug releasing time

First 80% of drug dosage can be released in first month. This controlled drug releasing rate can effectively prevent restenosis during intimal repairing progress

MSM Sirolimus Stent Design

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Double-helix lengthways structure shape provides excellent deliverability and conformability

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Sine wave design of horizontal structure provide uniform scaffolding and excellent support force

Well-balanced Support and Deliverability

MaterialCobalt Chromium
Strut thickness65 μm
Coating thickness3 - 5 μm
Metal-artery ratio15% - 18%
Balloon tip profile0.017" (0.43mm)
Lowest crossing profile0.035" (0.90mm)

A lot of published papers* showed that the use of a thinner strut stent is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting.

* “Intracoronary Stenting and Angiographic Results – Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial” , Adnan Kastraiti MD, Albert Schömig MD, 2001; 103:2816-2821, Circulation

* “In-Stent Restenosis in Small Coronary Arteries - Impact of Strut Thickness” , Carlo Briguori MD etc., Vol. 40, No. 3, 2002, Journal of the American College of Cardiology

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- Excellent Side Branch Access

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open cell design with 3 interlinks per segment

Diameter of mostly used device

  • Guidewire: BMW 0.014” (0.36mm)
  • Balloon Dilation Catheter: 0.024” (0.61mm)
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Delivery system of MSM DES Sirolimus

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Nominal inflation pressure is 8 atm

  • Hydrophilic coated distal shaft 1.9F shaft with a rapid deflation balloon
  • The balloon design optimizes a controlled linear expansion
  • A balloon overhang of <5 mm minimises vessel injury outside the stent

Technical Details Stent

Type of designopen cell design with 3 interlinks per segment
Design details9 crown per segment
MaterialCobalt-Chromium L605
Size Range2.25 mm - 4.00 mm
Strut thickness0.0026" ( 65μm )
Strut width (Main segment)0.0028" ( 72μm )
Strut width (interlink)0.0023" ( 58μm )
Shortening after expansion< 2%
Recoil< 5%
Sirolimus Matrix Thickness< 18%
3-5 μm
Guinding Catheter compatibility5 F

Technical Details Catheter

Usable length138 cm
Length of the guide wire lumen27 cm
Distal shaftPolyamide, Multi layer tubing
Proximal shaftStainless Steel with PTFE Coating
Shaft sizeProximal
Distal2.5 F - 2.9 F, depending on balloon size
Balloon foldingBalloon sizes 2.25 mm bis 2.5 mm
Balloon sizes 2.75 mm to 4.50 mm4-fold balloon
MarkerEmbedded Platinum/ Iridium Marker
Tip profile0.017" (0.43 mm)
Max. recommended guide wire0.014" (0.36 mm)

Specifications of MSM DES Sirolimus

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43 and 48 mm long stent, saving for both patients and doctors

Compliance Data

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Order Information

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