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MSM AG - The Pioneer
in Bio Active Stent Surface.

MSM - BMS (Bio Metal Surface) - Stent developed in 1996

After a few years of R&D work testing the biocompatibility of different metals - including Titanium - we found out that Tantalum had the best result. With this knowledge we developed in 1996 the first Bio Active Stent with a nano technology surface.

A new manufacturing process has been developed and used to implant Tantalum Ions into the stent surface based on a new plasma technology procedure with the result of a bio active Tantalum Oxide (Ta-O) stent surface.

Pure tantalum was used to obtain a tantalum atomic vaporisation. The combination of magnetic fields, vacuum, noble gas and simultaneous injections of nitrogen and oxygen are necessary to create ionisation and a plasma formation of Tantalum (Ta). Through a unique MSM process Tantalum Ions will be implanted until all the surfaces of the stent both inside and outside, consists completely of Ta-O nano particles. This surface is extremely smooth, dense and hard, making Tantalum Oxide (Ta-O) covered stents extremely well adapted for direct stenting where even the most calcified lesions cannot damage the stent surface.

However, the biggest challenge was to develop a process where the surface, which is comparable to a ceramic, would adhere homogeneously to the stainless steel or Cobalt-Chromium surfaces without any micro fractures after the stent expansion. Long term implanted MSM BMS stents show 25 years after stent implantation still best results.

This surface has been shown to remain intact after stent implantation without any sign of micro fractures, thus ensuring the bio active coating benefits, which is specifically active against both restenosis and thrombosis, as well as being an accelerator of re-endothelialisation.

MSM BMS was the first laser cutted slotted tube Bio Active Stent, made of medical grade stainless steel alloy with a thin atomic layer of implanted Tantalum Oxide (Ta-O).

MSM BMS was a bare stent or pre-mounted on a MSM PTCA balloon, rapid exchange, compatible with 0.014” guidewires and made of semi-compliant balloon material - a hydrophilic coating and its shaft characteristics enable kissing balloon procedures in 6F guiding catheters.

The stent platform was the bare metal benefiting from an unique and patented - United States Patent No: 6,497,723 B1 - design providing a extremely smooth nano surface, excellent flexibility, conformability as well as high radial force.

The MSM BMS Stent design allowed the use of thinner struts. These features result in optimized stent navigation inside the curved arteries and minimal stent induced trauma and inflammation due to this highly conformable patented structure. The unique design of the MSM BMS stent provided also ultra-low recoil and shortening. This platform enabled also the treatment of lesions located in bifurcations and gave an easier side branch access. MSM BMS Tantalum stent was available in various diameters and lengths and provided an unique design with a stent strut thickness at 60µm.

Publications:
Reduced surface corrosion of stents through tantalum treatment - A.W. Frey and H. Roskamm, Heart Center Bad Krozingen, Germany - S. Schwarzacher, Division of Cardiology, University of Innsbruck, Austria - B. Starck, MSM AG, Germany - A. Yeung, Division of Cardiovascular Medicine, Stanford, CA, USA

Tantalum coating reduces surface corrosion of stents - A.W. Frey and H. Roskamm, Kardiologie Herz Zentrum Bad Krozingen, Germany - S. Schwarzacher, Kardiologie Universität Innsbruck, Austria - M.CH. Tataru, Kardiologie Herz- und Gefässklinik Bad Neustadt, Germany - B. Starck - A. Yeung, Cardiology Stanford University Palo Alto United States of America - XXIst Congress of the ECS - Aug. 28th - Sep. 1st, 1999, Barcelona, Spain

Surface Corrosion of Stents is Highly Reduced by Tantalum Coating - A. Suciu and A.W.Frey, Heart Center Bad Krozingen, Germany - S. Schwarzacher, Division of Cardiology, University of Innsbruck, Austria - B. Starck, MSM AG, Germany - A. Yeung, Division of Cardiovascular Medicine, Stanford, CA, USA - Poster 65th Annual Congress of the German Cardiac Society - Heart and Circulatory Research, 8. - 10. April, 1999, Mannheim, Germany

The new MSM-Stent with tantalum surface by high-vacuum-metalisation-Effect to restenosis-rate and instent-thrombosis-rate - Jochen Wöhrle, Thorsten Nusser, Olaf Grebe, Matthias Kochs, Vinzenz Hombach, Martin Höher, Cardiology University of Ulm, Germany - 25th autumn-conference of the German Cardiological Society - heart- and circulation research Ulm, Germany, 27.-29. September 2001

Low restenosis and revascularization rate after implantation of the MSM stent with tantalum surface in a group with an increased risk of restenosis - J. Wöhrle, T. Nusser, O. Grebe, H.A. Kestler, M. Höher , Innere Medizin II – Kardiologie, Universität Ulm, Germany - 68th Annual Congress of the German Cardiac Society - Heart and Circulatory Research - April 04-06, 2002, Mannheim, Germany

Reduction of the restenosis rate through the use of a stent with a novel tantalum nanostructure surface – J. Wöhrle, T. Nusser, T. Habig, S. Schaible, M. Höher - 70th Annual Congress of the German Cardiac Society - Heart and Circulatory Research - April 15-17, 2004, Mannheim, Germany